Possible roles of platelet-derived microparticles in atherosclerosis

Atherosclerosis. 2016 May:248:10-6. doi: 10.1016/j.atherosclerosis.2016.03.004. Epub 2016 Mar 4.

Abstract

Platelets and platelet-derived microparticles (PMPs) play important roles in cardiovascular diseases, especially atherosclerosis. Continued research has revealed that PMPs have numerous functions in atherosclerosis, not only in thrombosis formation, but also by induction of inflammation. PMPs also induce formation of foam cells. Recent evidence strongly indicates a significant role of PMPs in atherosclerosis. Here, current research on the function of PMPs in atherosclerosis is reviewed.

Keywords: Atherosclerosis; Foam cells; Inflammation; PMPs; Thrombosis formation.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Atherosclerosis / blood*
  • Biomarkers / metabolism
  • Blood Coagulation
  • Blood Platelets / cytology*
  • Cell Adhesion
  • Cell-Derived Microparticles / metabolism*
  • Foam Cells / cytology
  • Humans
  • Inflammation
  • Lipid Metabolism
  • Lipids / chemistry
  • Neoplasms / metabolism
  • Platelet Activation

Substances

  • Biomarkers
  • Lipids