Dataset of mouse hippocampus profiled by LC-MS/MS for label-free quantitation

Jane A English; Caitriona Scaife; Akiko Harauma; Melanie Focking; Kieran Wynne; Gerard Cagney; Toru Moriguchi; David R Cotter

doi:10.1016/j.dib.2015.12.057

Dataset of mouse hippocampus profiled by LC-MS/MS for label-free quantitation

Data Brief. 2016 Feb 15:7:341-3. doi: 10.1016/j.dib.2015.12.057. eCollection 2016 Jun.

Authors

Jane A English¹, Caitriona Scaife², Akiko Harauma³, Melanie Focking⁴, Kieran Wynne², Gerard Cagney², Toru Moriguchi³, David R Cotter⁴

Affiliations

¹ Department of Psychiatry, Royal College of Surgeons in Ireland, ERC Beaumont Hospital, Dublin, Ireland; Proteome Research Centre, School of Medicine and Medical Science, UCD Conway Institute of Biomolecular and Biomedical Research, University College Dublin, Ireland.
² Proteome Research Centre, School of Medicine and Medical Science, UCD Conway Institute of Biomolecular and Biomedical Research, University College Dublin, Ireland.
³ Department of Food and Life Science, Azabu University, Sagamihara, Japan.
⁴ Department of Psychiatry, Royal College of Surgeons in Ireland, ERC Beaumont Hospital, Dublin, Ireland.

Abstract

This dataset reports on the analysis of mouse hippocampus by LC-MS/MS, from mice fed a diet that was either deficient in n-3 FA (n-3 Def) or sufficient in n-3 FA (n-3 Adq). Label free quantitative (LFQ) analysis of the mass spectrometry data identified 1008 quantifiable proteins, 115 of which were found to be differentially expressed between the two dietary groups (n=8 per group). This data article refers to the research article "Omega-3 fatty acid deficiency disrupts endocytosis, neuritogenesis, and mitochondrial protein pathways in the mouse hippocampus" (English et al., 2013 [1]), in which a more comprehensive interpretation and analysis of the data is given.

Keywords: Brain; Hippocampus; Mass spectrometry; Mouse; Omega-3 deficiency; Proteins; Proteomics.