Neutrophils: Critical components in experimental animal models of cancer

Semin Immunol. 2016 Apr;28(2):197-204. doi: 10.1016/j.smim.2016.02.003. Epub 2016 Mar 11.

Abstract

Neutrophils have a crucial role in tumor development and metastatic progression. The contribution of neutrophils in tumor development is multifaceted and contradictory. On the one hand, neutrophils prompt tumor inception, promote tumor development by mediating the initial angiogenic switch and facilitate colonization of circulating tumor cells, and on the other hand, have cytotoxic and anti-metastatic capabilities. Our understanding of the role of neutrophils in tumor development has greatly depended on different experimental animal models of cancer. In this review we cover important findings that have been made about neutrophils in experimental animal models of cancer, point to their advantages and limitations, and discuss novel techniques that can be used to expand our knowledge of how neutrophils influence tumor progression.

Keywords: Animal models; Neutrophil; Tumor development.

Publication types

  • Review
  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adaptive Immunity
  • Animals
  • Disease Models, Animal*
  • Disease Progression
  • Humans
  • Immunity, Innate
  • Neoplasm Metastasis
  • Neoplasms / etiology*
  • Neoplasms / metabolism*
  • Neoplasms / pathology
  • Neovascularization, Pathologic / immunology
  • Neovascularization, Pathologic / metabolism
  • Neutrophil Infiltration / immunology*
  • Neutrophils / immunology*
  • Neutrophils / metabolism*
  • Neutrophils / pathology
  • Tumor Microenvironment / immunology