Management of uveal tract melanoma: A comprehensive review

J Egypt Natl Canc Inst. 2016 Jun;28(2):65-72. doi: 10.1016/j.jnci.2016.02.003. Epub 2016 Mar 11.

Abstract

Uveal tract melanoma is the most common primary intraocular malignancy in adults, accounting for about 5-10% of all the melanomas. Since there are no lymphatic vessels in the eye, uveal melanoma can only spread hematogenously leading to liver metastasis. A wide variety of treatment modalities are available for its management, leading to dilemma in selecting the appropriate therapy. This article reviews the diagnostic and therapeutic modalities available and thus, can help to individualize the treatment plan for each patient.

Keywords: Management; Treatment modalities; Uveal tract melanoma.

Publication types

  • Review

MeSH terms

  • Adult
  • Biopsy, Fine-Needle
  • Brachytherapy / adverse effects
  • Eye / pathology
  • Eye Enucleation*
  • Fluorescein Angiography
  • Humans
  • Liver Neoplasms / diagnosis
  • Liver Neoplasms / secondary
  • Liver Neoplasms / therapy*
  • Low-Level Light Therapy / adverse effects
  • Melanoma / diagnosis*
  • Melanoma / pathology
  • Melanoma / radiotherapy*
  • Melanoma / surgery
  • Neoplasm Staging
  • Precision Medicine*
  • Prognosis
  • Proton Therapy / adverse effects
  • Tomography, X-Ray Computed
  • Ultrasonography
  • Uveal Neoplasms / diagnosis*
  • Uveal Neoplasms / pathology
  • Uveal Neoplasms / radiotherapy*
  • Uveal Neoplasms / surgery

Supplementary concepts

  • Uveal melanoma