We present a concept of a white-light-seeded-cascaded mid-infrared (mid-IR) optical parametric amplifier (OPA) based on potassium titanyl arsenate and zinc germanium phosphate nonlinear optical crystals and producing 100-μJ level pulses centered at 5300 nm, with the spectrum supporting four-optical-cycle pulse duration. The OPA is pumped by 2090-nm master oscillator/power amplifier based on a Tm,Ho-fiber laser seeder and a Ho:YAG regenerative amplifier delivering 3.8-mJ sub-ps pulses at a repetition rate of 1 kHz. We validate that output parameters of the OPA are scalable by means of increasing the pulse energy, decreasing the pulse duration and redshifting the central wavelength.