Effect of duodenal glucose load on blood pressure in type 2 diabetes

Chinmay S Marathe; Michael Horowitz; Laurence G Trahair; Michelle Bound; Helen Checklin; Kylie Lange; Christopher K Rayner; Karen L Jones

doi:10.1016/j.diabres.2016.01.024

Effect of duodenal glucose load on blood pressure in type 2 diabetes

Diabetes Res Clin Pract. 2016 Mar:113:38-40. doi: 10.1016/j.diabres.2016.01.024. Epub 2016 Jan 22.

Authors

Chinmay S Marathe¹, Michael Horowitz², Laurence G Trahair², Michelle Bound², Helen Checklin², Kylie Lange², Christopher K Rayner², Karen L Jones²

Affiliations

¹ Discipline of Medicine, University of Adelaide, Royal Adelaide Hospital, Adelaide, Australia; Centre of Research Excellence (CRE) in Translating Nutritional Science to Good Health, University of Adelaide, Adelaide, Australia. Electronic address: chinmaymarathe@gmail.com.
² Discipline of Medicine, University of Adelaide, Royal Adelaide Hospital, Adelaide, Australia; Centre of Research Excellence (CRE) in Translating Nutritional Science to Good Health, University of Adelaide, Adelaide, Australia.

PMID: 26972959
DOI: 10.1016/j.diabres.2016.01.024

Abstract

Postprandial hypotension occurs frequently in diabetes. We show in 9 type 2 patients, that the fall in systolic blood pressure is greater in response to intraduodenal glucose infused at 4 kcal/min than 2 kcal/min, implying that strategies to slow gastric emptying may be effective in the management of postprandial hypotension.

Keywords: Gastric emptying; Intraduodenal glucose; Postprandial blood pressure.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Blood Pressure / drug effects*
Diabetes Mellitus, Type 2 / drug therapy
Diabetes Mellitus, Type 2 / physiopathology*
Duodenum / drug effects*
Gastric Emptying / drug effects*
Glucose / pharmacology*
Heart Rate / drug effects*
Humans
Hypotension / drug therapy
Hypotension / physiopathology*
Male
Middle Aged
Postprandial Period / physiology
Sweetening Agents / pharmacology

Substances

Sweetening Agents
Glucose