Cytokines in the perinatal period - Part II

A Chau; J C Markley; J Juang; L C Tsen

doi:10.1016/j.ijoa.2015.12.006

Cytokines in the perinatal period - Part II

Int J Obstet Anesth. 2016 May:26:48-58. doi: 10.1016/j.ijoa.2015.12.006. Epub 2016 Jan 5.

Authors

A Chau¹, J C Markley², J Juang³, L C Tsen³

Affiliations

¹ Division of Obstetric Anesthesia, Department of Anesthesiology, Perioperative and Pain Medicine, Brigham and Women's Hospital, Boston, MA, USA; Harvard Medical School, Boston, MA, USA; Department of Anesthesiology, Pharmacology & Therapeutics, University of British Columbia, Vancouver, BC, Canada. Electronic address: antonchau1@gmail.com.
² Division of Obstetric Anesthesia, Department of Anesthesiology, Perioperative and Pain Medicine, Brigham and Women's Hospital, Boston, MA, USA; Harvard Medical School, Boston, MA, USA; Department of Anesthesia and Perioperative Care, San Francisco General Hospital, University of California San Francisco, San Francisco, CA, USA.
³ Division of Obstetric Anesthesia, Department of Anesthesiology, Perioperative and Pain Medicine, Brigham and Women's Hospital, Boston, MA, USA; Harvard Medical School, Boston, MA, USA.

PMID: 26971652
DOI: 10.1016/j.ijoa.2015.12.006

Abstract

A contemporary, robust immunologic explanation for common obstetric conditions remains elusive; why some pregnant women are more susceptible to developing preeclampsia or preterm labor is not completely understood. We explore the immunology behind four important and commonly encountered pregnancy-related conditions: preeclampsia, recurrent miscarriage, preterm labor and gestational diabetes. For each condition, we summarize the current understanding of cytokines implicated in the pathogenesis, discuss the impact of anesthesia and analgesia on selected cytokine profiles, and suggest potential opportunities for clinical and research interventions.

Publication types

Review

MeSH terms

Abortion, Habitual / immunology*
Cytokines / blood*
Diabetes, Gestational / immunology*
Female
Humans
Pre-Eclampsia / immunology*
Pregnancy
Premature Birth / immunology*

Substances

Cytokines