The Pluripotency of Neural Crest Cells and Their Role in Brain Development

Nicole M Le Douarin; Elisabeth Dupin

doi:10.1016/bs.ctdb.2015.10.008

The Pluripotency of Neural Crest Cells and Their Role in Brain Development

Curr Top Dev Biol. 2016:116:659-78. doi: 10.1016/bs.ctdb.2015.10.008. Epub 2016 Jan 20.

Authors

Nicole M Le Douarin¹, Elisabeth Dupin²

Affiliations

¹ Collège de France, 3 rue d'Ulm, Paris, France; INSERM U968, Paris, France; Sorbonne Universités, UPMC Univ Paris 06, UMR S 968, Institut de la Vision, Paris, France; CNRS, UMR 7210, Paris, France. Electronic address: nicole.le-douarin@college-de-france.fr.
² INSERM U968, Paris, France; Sorbonne Universités, UPMC Univ Paris 06, UMR S 968, Institut de la Vision, Paris, France; CNRS, UMR 7210, Paris, France.

PMID: 26970647
DOI: 10.1016/bs.ctdb.2015.10.008

Abstract

The neural crest (NC) is, in the Chordate phylum, an innovation of vertebrates, which exhibits several original characteristics: its component cells are pluripotent and give rise to both ectodermal and mesodermal cell types. Moreover, during the early stages of neurogenesis, the NC cells exert a paracrine stimulating effect on the development of the preotic brain.

Keywords: Brain; Ectomesenchyme; Evolution; FGF8; Lineage; Neural crest; Pluripotency.

Publication types

Research Support, Non-U.S. Gov't
Review

MeSH terms

Animals
Brain / growth & development*
Cell Differentiation*
Neural Crest / growth & development*
Neurogenesis / physiology*
Pluripotent Stem Cells / cytology*
Vertebrates / growth & development*