Cancer in Drosophila: Imaginal Discs as a Model for Epithelial Tumor Formation

Héctor Herranz; Teresa Eichenlaub; Stephen M Cohen

doi:10.1016/bs.ctdb.2015.11.037

Cancer in Drosophila: Imaginal Discs as a Model for Epithelial Tumor Formation

Curr Top Dev Biol. 2016:116:181-99. doi: 10.1016/bs.ctdb.2015.11.037. Epub 2016 Feb 1.

Authors

Héctor Herranz¹, Teresa Eichenlaub¹, Stephen M Cohen²

Affiliations

¹ Department of Cellular and Molecular Medicine, University of Copenhagen, Copenhagen, Denmark.
² Department of Cellular and Molecular Medicine, University of Copenhagen, Copenhagen, Denmark. Electronic address: scohen@sund.ku.dk.

PMID: 26970620
DOI: 10.1016/bs.ctdb.2015.11.037

Abstract

Cancer genomics has greatly increased our understanding of the complexity of the genetic and epigenetic changes found in human tumors. Understanding the functional relationships among these elements calls for the use of flexible genetic models. We discuss the use of Drosophila models to study cooperation among genetic factors that contribute to disease progression.

Keywords: Cancer; Disease model; Drosophila; EGFR; Epithelial–mesenchymal transition; Imaginal disc; Metastasis.

Publication types

Research Support, Non-U.S. Gov't
Review

MeSH terms

Animals
Disease Models, Animal
Drosophila / genetics*
Epithelial-Mesenchymal Transition / physiology*
Gene Expression Regulation, Neoplastic
Humans
Imaginal Discs / pathology*
Neoplasms / pathology*
Oncogenes