One new linear C14 polyacetylene glucoside with antiadipogenic activities on 3T3-L1 cells from the capitula of Coreopsis tinctoria

J Asian Nat Prod Res. 2016 Aug;18(8):784-90. doi: 10.1080/10286020.2016.1157077. Epub 2016 Mar 9.

Abstract

Based on characteristic UV spectrum of the ene-diyne chromophore, one new polyacetylene glucoside and three known polyacetylene glucosides have been isolated from the EtOH extract of Coreopsis tinctoria. Their chemical structures were determined by detailed spectroscopic analysis and by comparison with literature data. Compounds 1-2 were tested for their antiadipogenic effects on 3T3-L1 adipocytes, and both of them reduced lipid accumulation dose-dependently in 3T3-L1 adipocytes.

Keywords: 3T3-L1; Asteraceae; Coreopsis tinctoria; antiadipogenic effect; polyacetylene glucosides.

MeSH terms

  • 3T3-L1 Cells / drug effects
  • Adipocytes / drug effects*
  • Animals
  • Coreopsis / chemistry*
  • Drugs, Chinese Herbal / chemistry
  • Drugs, Chinese Herbal / isolation & purification*
  • Drugs, Chinese Herbal / pharmacology*
  • Flavonoids / pharmacology
  • Glucosides / chemistry
  • Glucosides / isolation & purification*
  • Glucosides / pharmacology*
  • Mice
  • Molecular Structure
  • Polyynes / chemistry
  • Polyynes / isolation & purification*
  • Polyynes / pharmacology*

Substances

  • Drugs, Chinese Herbal
  • Flavonoids
  • Glucosides
  • coreoside A
  • coreoside E
  • Polyynes