Glycopeptide antibiotic analogs for selective inactivation and two-photon imaging of vancomycin-resistant strains

Chem Commun (Camb). 2016 Mar 28;52(25):4667-70. doi: 10.1039/c5cc10230h.

Abstract

A novel theranostic divalent vancomycin analog using a planar 1,8-diazapyrene moiety as a rigid scaffold exhibits potent and selective antibacterial activity against Gram (+) bacteria including vancomycin-resistant strains, while having minimal influence on Gram (-) bacteria and mammalian cells. Moreover, this theranostic analog can be also applied for selective two-photon fluorescence imaging of Gram (+) bacteria.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Anti-Bacterial Agents / chemistry
  • Anti-Bacterial Agents / pharmacology
  • Glycopeptides / chemistry*
  • Glycopeptides / pharmacology*
  • Gram-Positive Bacteria / drug effects*
  • Gram-Positive Bacteria / metabolism
  • Gram-Positive Bacteria / ultrastructure
  • Humans
  • Microbial Sensitivity Tests
  • Microscopy, Electrochemical, Scanning
  • Molecular Structure
  • Optical Imaging
  • Vancomycin Resistance / drug effects*

Substances

  • Anti-Bacterial Agents
  • Glycopeptides