Abstract
A novel theranostic divalent vancomycin analog using a planar 1,8-diazapyrene moiety as a rigid scaffold exhibits potent and selective antibacterial activity against Gram (+) bacteria including vancomycin-resistant strains, while having minimal influence on Gram (-) bacteria and mammalian cells. Moreover, this theranostic analog can be also applied for selective two-photon fluorescence imaging of Gram (+) bacteria.
Publication types
-
Research Support, Non-U.S. Gov't
MeSH terms
-
Animals
-
Anti-Bacterial Agents / chemistry
-
Anti-Bacterial Agents / pharmacology
-
Glycopeptides / chemistry*
-
Glycopeptides / pharmacology*
-
Gram-Positive Bacteria / drug effects*
-
Gram-Positive Bacteria / metabolism
-
Gram-Positive Bacteria / ultrastructure
-
Humans
-
Microbial Sensitivity Tests
-
Microscopy, Electrochemical, Scanning
-
Molecular Structure
-
Optical Imaging
-
Vancomycin Resistance / drug effects*
Substances
-
Anti-Bacterial Agents
-
Glycopeptides