ARHGEF17 sets the timer for retention of Mps1 at kinetochores

Joseph R Marquardt; Harold A Fisk

doi:10.1083/jcb.201602060

ARHGEF17 sets the timer for retention of Mps1 at kinetochores

J Cell Biol. 2016 Mar 14;212(6):615-6. doi: 10.1083/jcb.201602060. Epub 2016 Mar 7.

Authors

Joseph R Marquardt¹, Harold A Fisk²

Affiliations

¹ Department of Molecular Genetics, The Ohio State University, Columbus, OH 43210.
² Department of Molecular Genetics, The Ohio State University, Columbus, OH 43210 fisk.13@osu.edu.

Abstract

The kinetochore-associated kinase Mps1 controls the spindle assembly checkpoint, but the regulation of its kinetochore recruitment and activity is unclear. In this issue, Isokane et al. (2016. J. Cell Biol. http://dx.doi.org/10.1083/jcb.201408089) show that interaction with and phosphorylation of its substrate, ARHGEF17, regulates Mps1 kinetochore retention, suggesting an autoregulated, timer-like mechanism.

Publication types

Comment

MeSH terms

Cell Cycle Checkpoints / physiology*
Cell Cycle Proteins / metabolism*
Humans
Kinetochores / metabolism*
Kinetochores / physiology*
Protein Serine-Threonine Kinases / metabolism*
Protein-Tyrosine Kinases / metabolism*
Rho Guanine Nucleotide Exchange Factors / metabolism*
Spindle Apparatus / metabolism*

Substances

Cell Cycle Proteins
Rho Guanine Nucleotide Exchange Factors
Protein-Tyrosine Kinases
Protein Serine-Threonine Kinases