Nitride coating enhances endothelialization on biomedical NiTi shape memory alloy

Mater Sci Eng C Mater Biol Appl. 2016 May:62:686-91. doi: 10.1016/j.msec.2016.02.031. Epub 2016 Feb 10.

Abstract

Surface nitriding was demonstrated to be an effective process for improving the biocompatibility of implantable devices. In this study, we investigated the benefits of nitriding the NiTi shape memory alloy for vascular stent applications. Results from cell experiments indicated that, compared to untreated NiTi, a superficial gas nitriding treatment enhanced the adhesion of human umbilical vein endothelial cells (HUVECs), cell spreading and proliferation. This investigation provides data to demonstrate the possibility of improving the rate of endothelialization on NiTi by means of nitride coating.

Keywords: Endothelialization; HUVEC; NiTi alloy; Surface nitriding.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Cell Adhesion / drug effects
  • Cell Proliferation / drug effects
  • Coated Materials, Biocompatible / chemistry*
  • Coated Materials, Biocompatible / pharmacology
  • Human Umbilical Vein Endothelial Cells
  • Humans
  • Materials Testing
  • Microscopy, Atomic Force
  • Microscopy, Electron, Scanning
  • Microscopy, Fluorescence
  • Nickel / chemistry*
  • Nickel / pharmacology
  • Surface Properties
  • Titanium / chemistry*
  • Titanium / pharmacology

Substances

  • Coated Materials, Biocompatible
  • titanium nickelide
  • Nickel
  • Titanium