Abstract
One new norlignan, namely noralashinol A (1), one known analogue (2), together with seven known lignans (3-9) were isolated from the stem barks of Syringa pinnatifolia. Their structures were elucidated extensively by spectroscopic methods, including mass spectrometry and 1D and 2D NMR spectroscopies. Compound 8 significantly inhibited NO production in LPS-induced BV-2 murine microglia cells with its IC50 value of 20.7 μM, compared to a positive control quercetin with its IC50 value of 15.3 μM.
Keywords:
Syringa pinnatifolia; anti-inflammatory activity; noralashinol A.
MeSH terms
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Animals
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Anti-Inflammatory Agents, Non-Steroidal / isolation & purification
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Anti-Inflammatory Agents, Non-Steroidal / pharmacology
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Cells, Cultured
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Drug Evaluation, Preclinical / methods
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Inhibitory Concentration 50
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Lignans / chemistry
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Lignans / isolation & purification
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Lignans / pharmacology
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Lipopolysaccharides / pharmacology
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Magnetic Resonance Spectroscopy
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Mass Spectrometry
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Mice
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Microglia / drug effects
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Molecular Structure
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Naphthols / isolation & purification
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Naphthols / pharmacology*
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Nitric Oxide / biosynthesis
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Plant Bark / chemistry
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Syringa / chemistry*
Substances
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Anti-Inflammatory Agents, Non-Steroidal
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Lignans
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Lipopolysaccharides
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Naphthols
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Nitric Oxide