Neutrophil-to-Lymphocyte Ratio Predicts Early Mortality in Patients with HBV-Related Decompensated Cirrhosis

Honggang Zhang; Qinqin Sun; Weilin Mao; Jian Fan; Bo Ye

doi:10.1155/2016/4394650

Neutrophil-to-Lymphocyte Ratio Predicts Early Mortality in Patients with HBV-Related Decompensated Cirrhosis

Gastroenterol Res Pract. 2016:2016:4394650. doi: 10.1155/2016/4394650. Epub 2016 Feb 2.

Authors

Honggang Zhang¹, Qinqin Sun², Weilin Mao³, Jian Fan³, Bo Ye³

Affiliations

¹ Department of Anesthesiology, The First Affiliated Hospital, College of Medicine, Zhejiang University, Zhejiang 310003, China.
² Department of Urology, The Sixth Affiliated Hospital of Xinjiang Medical University, Xinjiang 830001, China.
³ Department of Clinical Laboratory, The First Affiliated Hospital, College of Medicine, Zhejiang University, Zhejiang 310003, China.

Abstract

Background. The neutrophil-to-lymphocyte ratio (NLR) is an inflammation index that has been shown to independently predict poor clinical outcomes. We aimed to evaluate the clinical value of NLR in the prediction of 30-day mortality in patients with HBV-related decompensated cirrhosis (HBV-DeCi). Methods. This was a retrospective cohort study that included 148 patients with HBV-DeCi. Results. An elevated NLR was associated with increased severity of liver disease and mortality within 30 days. Multivariate analysis suggested that NLR, similar to the model for end-stage liver disease (MELD) score, is an additional independent predictor of 30-day mortality (P < 0.01). Conclusion. Our results suggest that a high NLR can be considered a new independent biomarker for predicting 30-day mortality in patients with HBV-DeCi.