1 From the Department of Translational Medical Sciences, Division of Clinical Physiology, Nagasaki University Graduate School of Biomedical Sciences (TS, TA); Division of Regenerative Oral Surgery, Department of Translational Medical Sciences, Nagasaki University Graduate School of Biomedical Sciences (KM); and Department of Special Care Dentistry, Nagasaki University Hospital, Nagasaki, Japan (TW).