Long noncoding RNAs in regulating adipogenesis: new RNAs shed lights on obesity

Cell Mol Life Sci. 2016 May;73(10):2079-87. doi: 10.1007/s00018-016-2169-2. Epub 2016 Mar 4.

Abstract

Long noncoding RNAs (lncRNAs) are an emerging class of regulators involved in a myriad of biological processes. Recent studies have revealed that many lncRNAs play pivotal roles in regulating adipocyte development. Due to the prevalence of obesity and the serious effects of adiposity on human health and society development, it is necessary to summarize functions and recent advances of lncRNAs in adipogenesis. In this review, we highlight functional lncRNAs contributed to the regulation of adipogenesis, discussing their potential use as therapeutic targets to combat human obesity.

Keywords: Adipose tissue; Beige cells; Blnc1; HOTAIR; NEAT1; SRA; ncRNAs.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Adipocytes / cytology
  • Adipogenesis / genetics
  • Adipogenesis / physiology*
  • Adipose Tissue / pathology*
  • Adipose Tissue, Brown / pathology
  • Adipose Tissue, White / pathology
  • Animals
  • Gene Expression Regulation
  • Humans
  • Obesity / genetics
  • Obesity / metabolism*
  • RNA, Long Noncoding / genetics*
  • RNA, Long Noncoding / metabolism*

Substances

  • HOTAIR long untranslated RNA, human
  • NEAT1 long non-coding RNA, human
  • RNA, Long Noncoding
  • boundary associated long noncoding RNA-1, human
  • steroid receptor RNA activator