The Experimental Research (In Vitro) of Carrageenans and Fucoidans to Decrease Activity of Hantavirus

Food Environ Virol. 2016 Jun;8(2):120-4. doi: 10.1007/s12560-016-9233-9. Epub 2016 Mar 4.

Abstract

The effect of carrageenans and fucoidans on the activity of Hantavirus is studied. It has been found that among carrageenans a significant antiviral effect is exerted by the ι-type, which decreases the viral titer by 2.5 log focus forming units per mL; among fucoidans, by a preparation from Laminaria cichorioides, which reduces the number of infected cells from 27.0 to 5.3 after pretreatment of both the macrophage culture and Hantavirus. The antiviral effect of fucoidan from Laminaria japonica is shown to grow in direct proportion to the increase of dose of the preparation.

Keywords: Carrageenans; Fucoidans; Hantaan virus; In vitro.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Carrageenan / isolation & purification
  • Carrageenan / pharmacology*
  • Laminaria / chemistry*
  • Orthohantavirus / drug effects*
  • Orthohantavirus / physiology
  • Plant Extracts / isolation & purification
  • Plant Extracts / pharmacology*
  • Polysaccharides / isolation & purification
  • Polysaccharides / pharmacology*
  • Seaweed / chemistry

Substances

  • Plant Extracts
  • Polysaccharides
  • Carrageenan
  • fucoidan