Abstract
The last 6 years have witnessed an explosion of discoveries at the interface of glycobiology and immunology. Binding of clustered oligosaccharides has turned out to be a very frequent mode by which human antibodies have developed broadly neutralizing activity against HIV. This mini-review will cover many recent developments in the HIV antibody field, as well as emerging data about Dengue broadly neutralizing antibodies.
Keywords:
Dengue broadly neutralizing antibodies; HIV broadly neutralizing antibodies; glycoproteins; multivalency; protein–carbohydrate interactions.
© The Author 2016. Published by Oxford University Press. All rights reserved. For permissions, please e-mail: journals.permissions@oup.com.
Publication types
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Review
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Research Support, N.I.H., Extramural
MeSH terms
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Antibodies, Neutralizing / chemistry*
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Antibodies, Neutralizing / immunology
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Antibodies, Neutralizing / metabolism
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Antibodies, Viral / chemistry*
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Antibodies, Viral / immunology
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Antibodies, Viral / metabolism
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Binding Sites
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Dengue / immunology
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Dengue / virology
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Dengue Virus / chemistry*
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Dengue Virus / immunology
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Epitopes / chemistry
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Epitopes / immunology
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Epitopes / metabolism
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HIV Envelope Protein gp120 / chemistry*
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HIV Envelope Protein gp120 / immunology
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HIV Envelope Protein gp120 / metabolism
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HIV Infections / immunology
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HIV Infections / virology
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HIV-1 / chemistry*
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HIV-1 / immunology
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Humans
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Models, Molecular
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Protein Binding
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Protein Conformation, alpha-Helical
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Protein Conformation, beta-Strand
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Protein Interaction Domains and Motifs
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Viral Envelope Proteins / chemistry*
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Viral Envelope Proteins / immunology
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Viral Envelope Proteins / metabolism
Substances
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Antibodies, Neutralizing
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Antibodies, Viral
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Epitopes
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HIV Envelope Protein gp120
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Viral Envelope Proteins
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glycoprotein E, dengue virus type 4