B-cell Lymphoproliferative Disorders Associated with Primary and Acquired Immunodeficiency

Abstract

The diagnosis of lymphoproliferative disorders associated with immunodeficiency can be challenging because many of these conditions have overlapping clinical and pathologic features and share similarities with their counterparts in the immunocompetent setting. There are subtle but important differences between these conditions that are important to recognize for prognostic and therapeutic purposes. This article provides a clinicopathologic update on how understanding of these B-cell lymphoproliferations in immunodeficiency has evolved over the past decade.

Keywords: Acquired immunodeficiency; B-Cell lymphoma; Post-transplant lymphoproliferative disorder; Primary immunodeficiency.