1 Division of Metabolism, Endocrinology and Nutrition (K.M.U.), Department of Medicine, VA Puget Sound Health Care System and the University of Washington, Seattle, Washington; Division of Public Health Sciences (M.K.), Fred Hutchinson Cancer Research Center, and the Department of Epidemiology, University of Washington, Seattle, Washington; Division of Gastroenterology (C.J.D.), Department of Medicine, University of Washington, Seattle, Washington; and Division of Public Health Sciences (M.H.), Fred Hutchinson Cancer Research Center, Seattle, Washington.
This review details potential mechanisms linking gut dysbiosis to metabolic dysfunction, including lipopolysaccharide, bile acids, short chain fatty acids, gut hormones, and branched-chain amino acids.