Hepatitis C Virus Exploitation of Processing Bodies

Jason M Biegel; Cara T Pager

doi:10.1128/JVI.03056-15

Hepatitis C Virus Exploitation of Processing Bodies

J Virol. 2016 Apr 29;90(10):4860-4863. doi: 10.1128/JVI.03056-15. Print 2016 May 15.

Authors

Jason M Biegel¹, Cara T Pager²

Affiliations

¹ Department of Biological Sciences, The RNA Institute, University at Albany, State University of New York, Albany, New York, USA.
² Department of Biological Sciences, The RNA Institute, University at Albany, State University of New York, Albany, New York, USA ctpager@albany.edu.

Abstract

During infection, positive-strand RNA viruses subvert cellular machinery involved in RNA metabolism to translate viral proteins and replicate viral genomes to avoid or disable the host defense mechanisms. Cytoplasmic RNA granules modulate the stabilities of cellular and viral RNAs. Understanding how hepatitis C virus and other flaviviruses interact with the host machinery required for protein synthesis, localization, and degradation of mRNAs is important for elucidating how these processes occur in both virus-infected and uninfected cells.

Publication types

Review
Research Support, Non-U.S. Gov't

MeSH terms

Cytoplasmic Granules / genetics
Cytoplasmic Granules / immunology
Cytoplasmic Granules / metabolism*
Cytoplasmic Granules / ultrastructure
Genome, Viral
Hepacivirus / genetics
Hepacivirus / immunology
Hepacivirus / physiology*
Host-Pathogen Interactions*
Humans
MicroRNAs / metabolism
RNA, Messenger / genetics
RNA, Messenger / metabolism*
RNA, Small Interfering / immunology
RNA, Viral / genetics
RNA, Viral / metabolism*

Substances

MicroRNAs
RNA, Messenger
RNA, Small Interfering
RNA, Viral

Grants and funding

This work is supported by funds to Cara Pager from the University at Albany and the State of New York and by a grant from the American Association for the Study of Liver Diseases (ASSLD) (to C.T.P.).