[How some commensal bacteria would exacerbate colorectal carcinogenesis?]

Med Sci (Paris). 2016 Feb;32(2):175-82. doi: 10.1051/medsci/20163202011. Epub 2016 Mar 2.
[Article in French]

Abstract

The gut microbiota maintains a relationship with its host with strong mutual benefits. Changes in the composition of the intestinal microbiota have been detected in colorectal cancer patients to the extent that it is now considered as a real contributing factor in this pathology. In this review, we focus on three commensal bacterial species, namely Bacteroides fragilis, Fusobacterium nucleatum, and Escherichia coli, which seem to emerge as pathogens and to contribute to colorectal carcinogenesis through their inflammatory and oncogenic properties.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Animals
  • Bacterial Physiological Phenomena*
  • Bacteroides fragilis / pathogenicity
  • Carcinogenesis / pathology
  • Colorectal Neoplasms / microbiology*
  • Colorectal Neoplasms / pathology*
  • Disease Progression
  • Escherichia coli / pathogenicity
  • Fusobacterium nucleatum / pathogenicity
  • Gastrointestinal Tract / microbiology
  • Gastrointestinal Tract / pathology
  • Humans
  • Symbiosis / physiology*