Burning cellular bridges: Two pathways to the big breakup

E B Frankel; Anjon Audhya

doi:10.1083/jcb.201602003

Burning cellular bridges: Two pathways to the big breakup

J Cell Biol. 2016 Feb 29;212(5):491-3. doi: 10.1083/jcb.201602003.

Authors

E B Frankel¹, Anjon Audhya²

Affiliations

¹ Department of Biomolecular Chemistry, University of Wisconsin-Madison School of Medicine and Public Health, Madison, WI 53706.
² Department of Biomolecular Chemistry, University of Wisconsin-Madison School of Medicine and Public Health, Madison, WI 53706 audhya@wisc.edu.

Abstract

During cytokinetic abscission, the endosomal sorting complex required for transport (ESCRT) proteins are recruited to the midbody and direct the severing of the intercellular bridge. In this issue, Christ et al. (2016. J. Cell Biol. http://dx.doi.org/10.1083/jcb.201507009) demonstrate that two separate but redundant pathways exist to recruit ESCRT-III proteins to the midbody.

Publication types

Comment

MeSH terms

Calcium-Binding Proteins / metabolism*
Cell Cycle Proteins / metabolism*
Cytokinesis*
Endosomal Sorting Complexes Required for Transport / metabolism*
Humans

Substances

Calcium-Binding Proteins
Cell Cycle Proteins
Endosomal Sorting Complexes Required for Transport

Grants and funding

T32 GM007215/GM/NIGMS NIH HHS/United States