Chemometric analysis of the interactions among different parameters describing health conditions, breast cancer risk and fatty acids profile in serum of rats supplemented with conjugated linoleic acids

Agnieszka Białek; Paweł Zagrodzki; Andrzej Tokarz

doi:10.1016/j.plefa.2015.12.006

Chemometric analysis of the interactions among different parameters describing health conditions, breast cancer risk and fatty acids profile in serum of rats supplemented with conjugated linoleic acids

Prostaglandins Leukot Essent Fatty Acids. 2016 Mar:106:1-10. doi: 10.1016/j.plefa.2015.12.006. Epub 2016 Feb 5.

Authors

Agnieszka Białek¹, Paweł Zagrodzki², Andrzej Tokarz³

Affiliations

¹ Department of Bromatology, Medical University of Warsaw, Banacha 1, 02-097 Warsaw, Poland. Electronic address: agnieszka.bialek@wum.edu.pl.
² Department of Food Chemistry and Nutrition, Jagiellonian University Medical College, Medyczna 9, 30-688 Cracow, Poland; H. Niewodniczański Institute of Nuclear Physics, Polish Academy of Sciences, Radzikowskiego 152, 31-342 Cracow, Poland. Electronic address: Pawel.Zagrodzki@ifj.edu.pl.
³ Department of Bromatology, Medical University of Warsaw, Banacha 1, 02-097 Warsaw, Poland. Electronic address: andrzej.tokarz@wum.edu.pl.

PMID: 26926361
DOI: 10.1016/j.plefa.2015.12.006

Abstract

We investigated how different doses of conjugated linoleic acids applied for various periods of time influence breast cancer risk and fatty acids profile in serum of rats treated or not with 7,12-dimethylbenz[a]anthracene (DMBA). We also search for interactions among parameters describing health conditions and cancer risk. Animals were divided into 18 groups with different diet modifications (vegetable oil, 1.0%, 2.0% additions of CLA) and different periods of supplementation. In groups treated with DMBA mammary adenocarcinomas appeared. Due to the complexity of experiment apart from statistical analysis a chemometric tool-Partial Least Square method was applied. Analysis of pairs of correlated parameters allowed to identify some regularities concerning the relationships between fatty acid profiles and clinical features of animals. Fatty acids profile was the result of prolonged exposure to high dose of CLA and DMBA administration. These two factors underlined the differences in fatty acids profiles among clusters of animals.

Keywords: Breast cancer; Cluster analysis; Fatty acids; PARTIAL Least Square.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

9,10-Dimethyl-1,2-benzanthracene / adverse effects*
Animals
Dietary Fats / administration & dosage
Dietary Fats / pharmacology
Dose-Response Relationship, Drug
Drug Administration Schedule
Fatty Acids / blood*
Female
Least-Squares Analysis
Linoleic Acids, Conjugated / administration & dosage*
Linoleic Acids, Conjugated / pharmacology
Mammary Neoplasms, Experimental / chemically induced*
Mammary Neoplasms, Experimental / metabolism
Rats
Risk Factors

Substances

Dietary Fats
Fatty Acids
Linoleic Acids, Conjugated
9,10-Dimethyl-1,2-benzanthracene