Extended-Synaptotagmins (E-Syts); the extended story

Chelsea Herdman; Tom Moss

doi:10.1016/j.phrs.2016.01.034

Extended-Synaptotagmins (E-Syts); the extended story

Pharmacol Res. 2016 May:107:48-56. doi: 10.1016/j.phrs.2016.01.034. Epub 2016 Feb 27.

Authors

Chelsea Herdman¹, Tom Moss²

Affiliations

¹ Laboratory of Growth and Development, St-Patrick Research Group in Basic Oncology, Cancer Division of the Québec University Hospital Research Centre, Department of Molecular Biology, Medical Biochemistry and Pathology, Faculty of Medicine, Laval University, Edifice St Patrick, 9 rue McMahon, Québec, QC G1R 3S3, Canada.
² Laboratory of Growth and Development, St-Patrick Research Group in Basic Oncology, Cancer Division of the Québec University Hospital Research Centre, Department of Molecular Biology, Medical Biochemistry and Pathology, Faculty of Medicine, Laval University, Edifice St Patrick, 9 rue McMahon, Québec, QC G1R 3S3, Canada. Electronic address: Tom.Moss@crhdq.ulaval.ca.

PMID: 26926095
DOI: 10.1016/j.phrs.2016.01.034

Abstract

The Extended-Synaptotagmin (E-Syt) membrane proteins were only recently discovered, but have already been implicated in a range of interrelated cellular functions, including calcium and receptor signaling, and membrane lipid transport. However, despite their evolutionary conservation and detailed studies of their molecular actions, we still have little idea of how and when these proteins are required in cellular and organism physiology. Here we review our present understanding of the E-Syts and discuss the molecular functions and in vivo requirements for these proteins.

Keywords: Calcium Signaling; ER-PM Tethering; EndoplasmicReticulum (ER) - Plasma Membrane(PM) Junctions; Extended Synaptotagmin (E-Syt,ESYT); FGF Signaling; Phospholipid Metabolism.

Publication types

Review
Research Support, Non-U.S. Gov't

MeSH terms

Animals
Humans
Protein Conformation
Signal Transduction
Synaptotagmins / chemistry
Synaptotagmins / metabolism*

Substances

Synaptotagmins