On the present and future of dissolution-DNP

Jan Henrik Ardenkjaer-Larsen

doi:10.1016/j.jmr.2016.01.015

On the present and future of dissolution-DNP

J Magn Reson. 2016 Mar:264:3-12. doi: 10.1016/j.jmr.2016.01.015.

Author

Jan Henrik Ardenkjaer-Larsen¹

Affiliation

¹ Technical University of Denmark, Department of Electrical Engineering, Kgs Lyngby, Denmark; GE Healthcare, Brøndby, Denmark.

PMID: 26920825
DOI: 10.1016/j.jmr.2016.01.015

Abstract

Dissolution-DNP is a method to create solutions of molecules with nuclear spin polarization close to unity. The many orders of magnitude signal enhancement have enabled many new applications, in particular in vivo MR metabolic imaging. The method relies on solid state dynamic nuclear polarization at low temperature followed by a dissolution to produce the room temperature solution of highly polarized spins. This work describes the present and future of dissolution-DNP in the mind of the author. The article describes some of the current trends in the field as well as outlines some of the areas where new ideas will make an impact. Most certainly, the future will take unpredicted directions, but hopefully the thoughts presented here will stimulate new ideas that can further advance the field.

Keywords: Dissolution-DNP; Hyperpolarization; Polarizer.

Publication types

Research Support, Non-U.S. Gov't