First description of past Hepatitis B Virus infection acute reactivation occurring in a Human Immunodeficiency Virus infected patient as manifestation of immune reconstitution inflammatory syndrome

Clémence Lepelletier; Maud Salmona; Béatrice Berçot; Sarah Maylin; Pierre-Olivier Sellier

doi:10.1016/j.jiac.2016.01.004

First description of past Hepatitis B Virus infection acute reactivation occurring in a Human Immunodeficiency Virus infected patient as manifestation of immune reconstitution inflammatory syndrome

J Infect Chemother. 2016 Jul;22(7):490-4. doi: 10.1016/j.jiac.2016.01.004. Epub 2016 Feb 23.

Authors

Clémence Lepelletier¹, Maud Salmona², Béatrice Berçot³, Sarah Maylin⁴, Pierre-Olivier Sellier¹

Affiliations

¹ Unité des Maladies Infectieuses et Tropicales, Département de Médecine Interne (Pr J-F Bergmann), APHP Hôpital Lariboisière, 2, rue Ambroise Paré, 75475 Paris Cedex 10, France.
² Laboratoire de Virologie (Pr F Simon), APHP Hôpital Saint-Louis, 1, avenue Claude Vellefaux, 75010 Paris, France; Université Paris Diderot, Sorbonne Paris Cité, Inserm U941, France. Electronic address: maud.salmona@aphp.fr.
³ Laboratoire de Microbiologie (Pr E Cambau), APHP Hôpital Lariboisière, 2, rue Ambroise Paré, 75475 Paris Cedex 10, France.
⁴ Laboratoire de Virologie (Pr F Simon), APHP Hôpital Saint-Louis, 1, avenue Claude Vellefaux, 75010 Paris, France.

PMID: 26919912
DOI: 10.1016/j.jiac.2016.01.004

Abstract

We report the case of an acute, self-resolving HBV-related hepatitis occurring in a HIV-infected patient carrying isolated anti-HBc antibodies. This acute HBV hepatitis may be considered as a clinical manifestation of a reactivation of HBV during an immune reconstitution inflammatory syndrome. Other hypotheses, even unlikely, are discussed.

Keywords: HBV reactivation; HIV; IRIS.

Publication types

Case Reports

MeSH terms

Adult
HIV Infections / complications*
Hepatitis B virus / physiology
Hepatitis B, Chronic / etiology*
Hepatitis B, Chronic / virology
Humans
Immune Reconstitution Inflammatory Syndrome / etiology*
Male
Virus Activation