Immune regulation in IgA nephropathy

R C Monteiro; L H Noël; A Chevailler; L Halbwachs-Mecarelli; P Lesavre

Immune regulation in IgA nephropathy

Nephrologie. 1989;10(3):147-50.

Authors

R C Monteiro¹, L H Noël, A Chevailler, L Halbwachs-Mecarelli, P Lesavre

Affiliation

¹ Département de Néphrologie et INSERM U 25, Hôpital Necker, Paris.

PMID: 2691912

Abstract

Regulation in IgA nephropathy (IgA N) has been largely studied. We present in this work our recent data which suggest that an abnormal chemical structure and/or molecular form of serum immunoglobulin A (IgA) might contribute to both the mesangial deposition of IgA and the T cell abnormalities which may in turn deregulate the IgA synthesis.

Publication types

Review

MeSH terms

Antigen-Antibody Complex / immunology
Glomerular Mesangium / immunology
Glomerulonephritis, IGA / immunology*
Homeostasis*
Humans
Immunity*
Immunoglobulin A / biosynthesis
Immunoglobulin A / immunology
Receptors, Fc / immunology
T-Lymphocytes / immunology

Substances

Antigen-Antibody Complex
Immunoglobulin A
Receptors, Fc