Ligand-Enabled Arylation of γ-C-H Bonds

Angew Chem Int Ed Engl. 2016 Mar 18;55(13):4317-21. doi: 10.1002/anie.201512020. Epub 2016 Feb 25.

Abstract

Pd(II) -catalyzed arylation of γ-C(sp(3) )-H bonds of aliphatic acid-derived amides was developed by using quinoline-based ligands. Various γ-aryl-α-amino acids were prepared from natural amino acids using this method. The influence of ligand structure on reactivity was also systematically investigated.

Keywords: arylation; carboxylic acids; palladium; quinoline ligand; γ-C-H activation.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Amino Acids / chemistry
  • Carbon / chemistry*
  • Hydrogen / chemistry*
  • Ligands

Substances

  • Amino Acids
  • Ligands
  • Carbon
  • Hydrogen