Regulation of IL-10 and IL-12 production and function in macrophages and dendritic cells

Xiaojing Ma; Wenjun Yan; Hua Zheng; Qinglin Du; Lixing Zhang; Yi Ban; Na Li; Fang Wei

doi:10.12688/f1000research.7010.1

Regulation of IL-10 and IL-12 production and function in macrophages and dendritic cells

F1000Res. 2015 Dec 17:4:F1000 Faculty Rev-1465. doi: 10.12688/f1000research.7010.1. eCollection 2015.

Authors

Xiaojing Ma¹, Wenjun Yan², Hua Zheng², Qinglin Du², Lixing Zhang², Yi Ban³, Na Li², Fang Wei²

Affiliations

¹ State Key Laboratory of Microbial Metabolism, Sheng Yushou Center of Cell Biology and Immunology, School of Life Science and Biotechnology, Shanghai Jiaotong University, Shanghai, USA; Department of Microbiology and Immunology, Weill Cornell Medical College, New York, NY, USA.
² State Key Laboratory of Microbial Metabolism, Sheng Yushou Center of Cell Biology and Immunology, School of Life Science and Biotechnology, Shanghai Jiaotong University, Shanghai, USA.
³ Department of Microbiology and Immunology, Weill Cornell Medical College, New York, NY, USA.

Abstract

Interleukin-10 and Interleukin-12 are produced primarily by pathogen-activated antigen-presenting cells, particularly macrophages and dendritic cells. IL-10 and IL-12 play very important immunoregulatory roles in host defense and immune homeostasis. Being anti- and pro-inflammatory in nature, respectively, their functions are antagonistically opposing. A comprehensive and in-depth understanding of their immunological properties and signaling mechanisms will help develop better clinical intervention strategies in therapy for a wide range of human disorders. Here, we provide an update on some emerging concepts, controversies, unanswered questions, and opinions regarding the immune signaling of IL-10 and IL-12.

Keywords: IL-10; IL-12; immune signaling.

Publication types

Review

Grants and funding

This work was supported in part by a grant from the Natural Science Foundation of China (31370903) to XM and by a grant from the National Institutes of Health of the US (1R21AI101841-01) to XM.