Nanomedicine Approaches to Modulate Neural Stem Cells in Brain Repair

Trends Biotechnol. 2016 Jun;34(6):437-439. doi: 10.1016/j.tibtech.2016.02.003. Epub 2016 Feb 22.

Abstract

We explore the concept of modulating neural stem cells and their niches for brain repair using nanotechnology-based approaches. These approaches include stimulating cell proliferation, recruitment, and differentiation to functionally recover damaged areas. Nanoscale-engineered materials potentially overcome limited crossing of the blood-brain barrier, deficient drug delivery, and cell targeting.

Keywords: brain repair; nanomedicine; nanoparticles; neural stem cells; neurodegenerative diseases; neuronal differentiation.

Publication types

  • Review
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Biocompatible Materials / chemical synthesis
  • Brain / cytology*
  • Brain / drug effects*
  • Cell Differentiation / drug effects
  • Humans
  • Nanoparticles / administration & dosage*
  • Nanoparticles / chemistry*
  • Nanoparticles / ultrastructure
  • Nerve Regeneration / drug effects*
  • Neural Stem Cells / cytology*
  • Neural Stem Cells / drug effects*

Substances

  • Biocompatible Materials