Controlled self-assembly of biomolecular rods on structured substrates

Soft Matter. 2016 Apr 7;12(13):3177-83. doi: 10.1039/c6sm00073h. Epub 2016 Feb 26.

Abstract

We report on the evaporative self-assembly and orientational ordering of semi-flexible spherocylindrical M13 phages on asymmetric stranded webs of thin amorphous carbon films. Although the phages were dispersed with a low concentration in the isotropic phase, the substrate edges induced nematic ordering and bending of the phages. As revealed by transmission electron microscopy, phages were aligned parallel to the curved substrate edges. This two-dimensional self-assembly on structured substrates opens a new route to the design of structures of orientationally ordered semi-flexible biomacromolecules.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Bacteriophage M13 / chemistry*
  • Bacteriophage M13 / physiology
  • Elastic Modulus
  • Microscopy, Electron, Transmission