Chemical Constituents of Plants from the Genus Phlegmariurus

Chem Biodivers. 2016 Mar;13(3):269-274. doi: 10.1002/cbdv.201500043.

Abstract

Phlegmariurus is a genus of ca. 200 species in the family Huperziaceae. Up to now, six species of the Phlegmariurus genus have been chemically investigated, and 89 compounds, including Lycopodium alkaloids possessing diverse structures and serratane-type triterpenes, have been isolated. These compounds show potent bioactivities, such as acetylcholinesterase inhibitory and cytotoxic activities.

Keywords: Biological activity; Huperziaceae; Lycopodium alkaloids; Phlegmariurus; Serratane-type triterpenes.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Acetylcholinesterase / metabolism
  • Alkaloids / chemistry
  • Alkaloids / isolation & purification
  • Alkaloids / pharmacology*
  • Cell Proliferation / drug effects
  • Cholinesterase Inhibitors / chemistry
  • Cholinesterase Inhibitors / isolation & purification
  • Cholinesterase Inhibitors / pharmacology*
  • Dose-Response Relationship, Drug
  • Humans
  • Huperzia / chemistry*
  • Molecular Structure
  • Plant Extracts / chemistry*
  • Plant Extracts / isolation & purification
  • Plant Extracts / pharmacology*
  • Structure-Activity Relationship
  • Triterpenes / chemistry
  • Triterpenes / isolation & purification
  • Triterpenes / pharmacology*

Substances

  • Alkaloids
  • Cholinesterase Inhibitors
  • Plant Extracts
  • Triterpenes
  • Acetylcholinesterase