Abstract
We report investigation of 22 TB cases with positive Xpert MTB/RIF result for resistance to Rifampin and "Very Low" MTB detection level. Twelve cases were false positive without rpoB mutations, 2 were false-positives with a silent mutation in rpoB codon T508, and only 10 were true positives.
Keywords:
Developing and high-burden countries; MDR-TB; Molecular diagnostics; Tuberculosis; Xpert MTB/RIF.
Copyright © 2016 Elsevier Inc. All rights reserved.
Publication types
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Research Support, N.I.H., Extramural
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Research Support, U.S. Gov't, Non-P.H.S.
MeSH terms
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Bacterial Load*
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Humans
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Microbial Sensitivity Tests*
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Mutation
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Mycobacterium tuberculosis / drug effects*
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Mycobacterium tuberculosis / genetics*
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Real-Time Polymerase Chain Reaction*
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Reproducibility of Results
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Rifampin / pharmacology*
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Sputum / microbiology
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Tuberculosis, Multidrug-Resistant / diagnosis*
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Tuberculosis, Multidrug-Resistant / microbiology*
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Tuberculosis, Pulmonary / diagnosis
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Tuberculosis, Pulmonary / microbiology