Adenosine-Activated Nanochannels Inspired by G-Protein-Coupled Receptors

Pei Li; Xiang-Yu Kong; Ganhua Xie; Kai Xiao; Zhen Zhang; Liping Wen; Lei Jiang

doi:10.1002/smll.201503863

Adenosine-Activated Nanochannels Inspired by G-Protein-Coupled Receptors

Small. 2016 Apr 13;12(14):1854-8. doi: 10.1002/smll.201503863. Epub 2016 Feb 24.

Authors

Pei Li¹, Xiang-Yu Kong², Ganhua Xie³, Kai Xiao³, Zhen Zhang³, Liping Wen², Lei Jiang^{1

2}

Affiliations

¹ Key Laboratory of Bio-Inspired Smart Interfacial Science and Technology of Ministry of Education, School of Chemistry and Environment, Beihang University, Beijing, 100191, P. R. China.
² Laboratory of Bioinspired Smart Interfacial Science, Technical Institute of Physics and Chemistry, Chinese Academy of Sciences, Beijing, 100190, P. R. China.
³ Beijing National Laboratory for Molecular Sciences (BNLMS), Key Laboratory of Green Printing, Institute of Chemistry, Chinese Academy of Sciences, Beijing, 100190, P. R. China.

PMID: 26915491
DOI: 10.1002/smll.201503863

Abstract

A bioinspired adenosine activated nanodevice is demonstrated in which the conformations of the designed aptamer change and cause signal transmission according to the emergence of adenosine. This bioinspired system exhibits very high response ratios (activated/nonactivated ratio up to 614) and excellent stability and reversibility, and shows promising applications in the fields of biosensors, pharmaceutica, and healthcare systems.

Keywords: adenosine; aptamers; bioinspired; nanochannels; nanodevices.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Adenosine / pharmacology*
Circular Dichroism
DNA / chemistry
Receptors, G-Protein-Coupled / chemistry*

Substances

Receptors, G-Protein-Coupled
DNA
Adenosine