Single-Step Fabrication of High-Density Microdroplet Arrays of Low-Surface-Tension Liquids

Wenqian Feng; Linxian Li; Xin Du; Alexander Welle; Pavel A Levkin

doi:10.1002/adma.201505972

Single-Step Fabrication of High-Density Microdroplet Arrays of Low-Surface-Tension Liquids

Adv Mater. 2016 Apr;28(16):3202-8. doi: 10.1002/adma.201505972. Epub 2016 Feb 24.

Authors

Wenqian Feng^{1

2}, Linxian Li^{1

2}, Xin Du^{1

3}, Alexander Welle⁴, Pavel A Levkin^{1

3}

Affiliations

¹ Institute of Toxicology and Genetics, Karlsruhe Institute of Technology, 76021, Karlsruhe, Germany.
² Institut für Organische Chemie, Ruprecht-Karls Universität Heidelberg, 69120, Heidelberg, Germany.
³ Department of Applied Physical Chemistry, Heidelberg University, 69120, Heidelberg, Germany.
⁴ Institute of Functional Interfaces, Karlsruhe Nano Micro Facility, Karlsruhe Institute of Technology, 76021, Karlsruhe, Germany.

PMID: 26915480
DOI: 10.1002/adma.201505972

Abstract

A facile approach for surface patterning that enables single-step fabrication of high-density arrays of low-surface-tension organic-liquid microdroplets is described. This approach enables miniaturized and parallel high-throughput screenings in organic solvents, formation of homogeneous arrays of hydrophobic nanoparticles, polymer micropads of specific shapes, and polymer microlens arrays.

Keywords: click chemistry; droplet arrays; high-throughput screening; microlens arrays; patterning.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

High-Throughput Screening Assays / instrumentation*
High-Throughput Screening Assays / methods
Hydrophobic and Hydrophilic Interactions
Microarray Analysis / instrumentation*
Microarray Analysis / methods
Nanoparticles / analysis
Nanoparticles / chemistry
Polymers / analysis
Polymers / chemistry
Solvents / chemistry*
Surface Tension

Substances

Polymers
Solvents