The features of skin inflammation induced by lupus serum

Clin Immunol. 2016 Apr:165:4-11. doi: 10.1016/j.clim.2016.02.007. Epub 2016 Feb 18.

Abstract

We recently developed a model of lupus serum-induced skin inflammation, which was used to study the pathogenesis of skin injury in systemic lupus erythematosus (SLE). We further characterized the features of lupus serum-induced skin inflammation. This skin inflammation was evident within 3h and lasted for at least two weeks. The skin inflammation was characterized by an influx of monocytic, CD11b+cells and by a scarcity of T and B lymphocytes. Depletion of IgG from the serum abrogated the skin inflammatory response. The skin inflammation was related to lupus patients' skin history but not to SLE disease activity and type of autoantibody. The expression of TNFR1, NF-kB and MCP-1 was increased locally in skin lesions. The TLR9 ligand and lupus serum act synergistically to trigger skin inflammation. These findings suggest that this novel model is valuable for the study of the pathogenesis and therapy of skin injury in SLE.

Keywords: IgG; Lupus serum; Skin inflammation; Systemic lupus erythematosus.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Autoantibodies / blood
  • Cytokines / blood
  • Disease Models, Animal
  • Dose-Response Relationship, Immunologic
  • Humans
  • Immune Sera / pharmacology*
  • Immunoglobulin G / blood
  • Immunoglobulin G / pharmacology
  • Immunohistochemistry
  • Inflammation / etiology*
  • Lupus Erythematosus, Systemic / blood*
  • Mice
  • Mice, Inbred BALB C
  • Mice, Inbred C57BL
  • Mice, Inbred MRL lpr
  • Serum / immunology*
  • Skin / drug effects*
  • Skin / pathology

Substances

  • Autoantibodies
  • Cytokines
  • Immune Sera
  • Immunoglobulin G