H9N2 avian influenza virus-derived natural reassortant H5N2 virus in swan containing the hemagglutinin segment from Eurasian H5 avian influenza virus with an in-frame deletion of four basic residues in the polybasic hemagglutinin cleavage site

Youling Wang; Xiaoyuan Yuan; Lihong Qi; Yuxia Zhang; Huaiying Xu; Jinxing Yang; Wu Ai; Wenbao Qi; Ming Liao; Dan Wang; Minxun Song; Feng Li

doi:10.1016/j.meegid.2016.02.022

H9N2 avian influenza virus-derived natural reassortant H5N2 virus in swan containing the hemagglutinin segment from Eurasian H5 avian influenza virus with an in-frame deletion of four basic residues in the polybasic hemagglutinin cleavage site

Infect Genet Evol. 2016 Jun:40:17-20. doi: 10.1016/j.meegid.2016.02.022. Epub 2016 Feb 22.

Authors

Youling Wang¹, Xiaoyuan Yuan¹, Lihong Qi¹, Yuxia Zhang¹, Huaiying Xu¹, Jinxing Yang¹, Wu Ai¹, Wenbao Qi², Ming Liao², Dan Wang³, Minxun Song⁴, Feng Li⁵

Affiliations

¹ Institute of Poultry Science, Shandong Academy of Agricultural Sciences, Jinan, China.
² College of Veterinary Medicine, South China Agricultural University, Guangzhou, China.
³ Department of Biology and Microbiology, South Dakota State University, Brookings, SD, USA.
⁴ Institute of Poultry Science, Shandong Academy of Agricultural Sciences, Jinan, China. Electronic address: mxsong@aliyun.com.
⁵ Institute of Poultry Science, Shandong Academy of Agricultural Sciences, Jinan, China; Department of Biology and Microbiology, South Dakota State University, Brookings, SD, USA; Department of Veterinary and Biomedical Science, South Dakota State University, Brookings, SD, USA. Electronic address: feng.li@sdstate.edu.

PMID: 26910357
DOI: 10.1016/j.meegid.2016.02.022

Abstract

We isolated a novel H5N2 avian influenza virus from swans in China. The virus was derived from a widespread H9N2 avian influenza virus but acquired the hemagglutinin gene from Eurasian H5 subtype with a naturally occurring in-frame deletion of four basic residues in the polybasic hemagglutinin cleavage site.

Keywords: Avian influenza virus; H5N2 subtype; H9N2 subtype; Hemagglutinin gene; Polybasic hemagglutinin cleavage site; Swan.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Animals
Birds / virology*
Genome, Viral
Hemagglutinin Glycoproteins, Influenza Virus / genetics*
Influenza A Virus, H5N2 Subtype / genetics
Influenza A virus / classification*
Influenza A virus / genetics
Phylogeny
Reassortant Viruses / classification*
Reassortant Viruses / genetics
Sequence Analysis, RNA / methods*
Sequence Deletion

Substances

Hemagglutinin Glycoproteins, Influenza Virus