Sophora flavescens (Ku-Shen) as a booster for antiretroviral therapy through cytochrome P450 3A4 inhibition

Hong Kong Med J. 2015 Dec:21 Suppl 7:S18-21.

Authors

Z X Lin¹, C T Che², S S Lee³, R C Y Chan⁴, P S P Ip¹, J M Yang¹

Affiliations

¹ School of Chinese Medicine, School of Biomedical Science, The Chinese University of Hong Kong.
² School of Chinese Medicine, School of Biomedical Science, The Chinese University of Hong Kong & Department of Medicinal Chemistry and Pharmacognosy, University of Illinois at Chicago, Chicago, USA.
³ Department of Microbiology & Stanley Ho Centre for Emerging Infectious Diseases, The Chinese University of Hong Kong.
⁴ Department of Microbiology, The Chinese University of Hong Kong.

PMID: 26908268

No abstract available

Publication types

Comparative Study
Research Support, Non-U.S. Gov't

MeSH terms

ATP Binding Cassette Transporter, Subfamily B, Member 1 / metabolism
Animals
Caco-2 Cells
Cytochrome P-450 CYP3A / drug effects*
Cytochrome P-450 CYP3A / metabolism
Cytochrome P-450 CYP3A Inhibitors / administration & dosage
Cytochrome P-450 CYP3A Inhibitors / isolation & purification
Cytochrome P-450 CYP3A Inhibitors / pharmacology*
Dose-Response Relationship, Drug
Herb-Drug Interactions
Humans
Indinavir / pharmacokinetics
Plant Extracts / administration & dosage
Plant Extracts / pharmacology*
Rats
Ritonavir / pharmacology
Sophora / chemistry*
Up-Regulation

Substances

ATP Binding Cassette Transporter, Subfamily B, Member 1
Cytochrome P-450 CYP3A Inhibitors
Plant Extracts
Indinavir
Cytochrome P-450 CYP3A
CYP3A4 protein, human
Ritonavir