In vitro activity of tedizolid against staphylococci isolated from prosthetic joint infections

Diagn Microbiol Infect Dis. 2016 May;85(1):77-9. doi: 10.1016/j.diagmicrobio.2016.01.008. Epub 2016 Jan 12.

Abstract

We determined the MIC and minimum biofilm bactericidal concentration (MBBC) of tedizolid and vancomycin against 97 isolates of Staphylococcus aureus and 74 isolates of Staphylococcus epidermidis associated with prosthetic joint infection. All isolates were vancomycin susceptible in the planktonic state; all staphylococci studied had a tedizolid MIC ≤0.5 μg/mL. The MBBC90 was >32 and >128 μg/mL for tedizolid and vancomycin, respectively.

Keywords: Biofilm; Staph aureus; Tedizolid.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Anti-Bacterial Agents / pharmacology*
  • Arthritis, Infectious / microbiology*
  • Humans
  • Inhibitory Concentration 50
  • Methicillin-Resistant Staphylococcus aureus
  • Microbial Sensitivity Tests*
  • Organophosphates / pharmacology*
  • Oxazoles / pharmacology*
  • Prosthesis-Related Infections / microbiology*
  • Staphylococcal Infections / microbiology*
  • Staphylococcus / classification
  • Staphylococcus / drug effects*
  • Staphylococcus / isolation & purification

Substances

  • Anti-Bacterial Agents
  • Organophosphates
  • Oxazoles
  • tedizolid phosphate