Abstract
We determined the MIC and minimum biofilm bactericidal concentration (MBBC) of tedizolid and vancomycin against 97 isolates of Staphylococcus aureus and 74 isolates of Staphylococcus epidermidis associated with prosthetic joint infection. All isolates were vancomycin susceptible in the planktonic state; all staphylococci studied had a tedizolid MIC ≤0.5 μg/mL. The MBBC90 was >32 and >128 μg/mL for tedizolid and vancomycin, respectively.
Keywords:
Biofilm; Staph aureus; Tedizolid.
Copyright © 2016 Elsevier Inc. All rights reserved.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Anti-Bacterial Agents / pharmacology*
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Arthritis, Infectious / microbiology*
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Humans
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Inhibitory Concentration 50
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Methicillin-Resistant Staphylococcus aureus
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Microbial Sensitivity Tests*
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Organophosphates / pharmacology*
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Oxazoles / pharmacology*
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Prosthesis-Related Infections / microbiology*
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Staphylococcal Infections / microbiology*
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Staphylococcus / classification
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Staphylococcus / drug effects*
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Staphylococcus / isolation & purification
Substances
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Anti-Bacterial Agents
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Organophosphates
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Oxazoles
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tedizolid phosphate