Biocompatible hydrogelators based on bile acid ethyl amides

Riikka Kuosmanen; Rakesh Puttreddy; Roosa-Maria Willman; Ilkka Äijäläinen; Adéla Galandáková; Jitka Ulrichová; Hannu Salo; Kari Rissanen; Elina Sievänen

doi:10.1016/j.steroids.2016.02.014

Biocompatible hydrogelators based on bile acid ethyl amides

Steroids. 2016 Apr:108:7-16. doi: 10.1016/j.steroids.2016.02.014. Epub 2016 Feb 22.

Authors

Riikka Kuosmanen¹, Rakesh Puttreddy¹, Roosa-Maria Willman¹, Ilkka Äijäläinen¹, Adéla Galandáková², Jitka Ulrichová², Hannu Salo¹, Kari Rissanen¹, Elina Sievänen³

Affiliations

¹ University of Jyvaskyla, Department of Chemistry, P.O. Box 35, FI-40014 University of Jyvaskyla, Finland.
² Palacký University in Olomouc, Department of Medical Chemistry and Biochemistry, Hněvotínská 3, CZ-775 15 Olomouc, Czech Republic.
³ University of Jyvaskyla, Department of Chemistry, P.O. Box 35, FI-40014 University of Jyvaskyla, Finland. Electronic address: elina.i.sievanen@jyu.fi.

PMID: 26905616
DOI: 10.1016/j.steroids.2016.02.014

Abstract

Four novel bile acid ethyl amides were synthetized using a well-known method. All the four compounds were characterized by IR, SEM, and X-ray crystal analyses. In addition, the cytotoxicity of the compounds was tested. Two of the prepared compounds formed organogels. Lithocholic acid derivative 1 formed hydrogels as 1% and 2% (w/v) in four different aqueous solutions. This is very intriguing regarding possible uses in biomedicine.

Keywords: Amide; Bile acid; Biocompatibility; Self-assembly; Supramolecular hydrogel.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

3T3 Cells
Amides / chemistry*
Animals
Biocompatible Materials / chemical synthesis
Biocompatible Materials / chemistry*
Biocompatible Materials / toxicity
Hydrogels / chemistry*
Lithocholic Acid / chemical synthesis
Lithocholic Acid / chemistry*
Lithocholic Acid / toxicity
Mice
Models, Molecular
Molecular Conformation
Water / chemistry

Substances

Amides
Biocompatible Materials
Hydrogels
Water
Lithocholic Acid