Screening for hepatocellular carcinoma in high-risk populations

Zoe A Miller; Kyungmouk Steve Lee

doi:10.1016/j.clinimag.2015.11.010

Screening for hepatocellular carcinoma in high-risk populations

Clin Imaging. 2016 Mar-Apr;40(2):311-4. doi: 10.1016/j.clinimag.2015.11.010. Epub 2015 Nov 23.

Authors

Zoe A Miller¹, Kyungmouk Steve Lee²

Affiliations

¹ Department of Radiology, Weill Cornell Medical College, New York, NY 10065.
² Department of Radiology, Weill Cornell Medical College, New York, NY 10065. Electronic address: ksl2001@med.cornell.edu.

PMID: 26898986
DOI: 10.1016/j.clinimag.2015.11.010

Abstract

Screening for hepatocellular carcinoma (HCC) should be implemented in the high-risk population. High-risk population includes patients with cirrhosis of any etiology, patients with chronic hepatitis B virus with or without cirrhosis, and patients with chronic hepatitis C virus with cirrhosis. A randomized controlled trial of over 18,000 high-risk individuals demonstrated that biannual screening reduced HCC-related mortality by 37%. The screening test of choice is ultrasound imaging with an interval of 6 months.

Keywords: Cirrhosis; Hepatitis B; Hepatitis C; Hepatocellular carcinoma screening; Liver cancer screening.

Publication types

Review

MeSH terms

Carcinoma, Hepatocellular / diagnosis*
Carcinoma, Hepatocellular / epidemiology
Early Detection of Cancer / methods*
Global Health
Humans
Liver Neoplasms / diagnosis*
Liver Neoplasms / epidemiology
Male
Morbidity / trends
Risk Factors
Survival Rate / trends