PtW/MoS2 hybrid nanocomposite for electrochemical sensing of H2O2 released from living cells

Lilian Zhu; Yuan Zhang; Pengcheng Xu; Weijia Wen; Xinxin Li; Jiaqiang Xu

doi:10.1016/j.bios.2016.02.019

PtW/MoS2 hybrid nanocomposite for electrochemical sensing of H2O2 released from living cells

Biosens Bioelectron. 2016 Jun 15:80:601-606. doi: 10.1016/j.bios.2016.02.019. Epub 2016 Feb 13.

Authors

Lilian Zhu¹, Yuan Zhang², Pengcheng Xu³, Weijia Wen⁴, Xinxin Li³, Jiaqiang Xu⁵

Affiliations

¹ Materials Genome Institute, Shanghai University, Shanghai 200444, China; Department of Chemistry, Shanghai University, Shanghai 200444, China.
² Materials Genome Institute, Shanghai University, Shanghai 200444, China; State Key Laboratory of Transducer Technology, Shanghai Institute of Microsystem and Information Technology, Chinese Academy of Sciences, Shanghai 200050, China. Electronic address: zhangyuan@shu.edu.cn.
³ State Key Laboratory of Transducer Technology, Shanghai Institute of Microsystem and Information Technology, Chinese Academy of Sciences, Shanghai 200050, China.
⁴ Materials Genome Institute, Shanghai University, Shanghai 200444, China.
⁵ Department of Chemistry, Shanghai University, Shanghai 200444, China. Electronic address: xujiaqiang@shu.edu.cn.

PMID: 26897262
DOI: 10.1016/j.bios.2016.02.019

Abstract

Hydrogen peroxide (H2O2) as an important reactive oxygen species (ROS) is reactive and potentially harmful to cells, causing oxidation of lipids, proteins and DNA. Herein, we report a PtW/MoS2 hybrid nanocomposite with ultrasensitive and highly specific response for the detection of H2O2 released from breast cancer 4T1 cells. Upon exposure to 5 nM of H2O2, the electrochemical response is still visible. This PtW/MoS2 hybrid nanocomposite could be facilely synthesized through in-situ growth of PtW nanocrystals on the surface of MoS2 nanosheets. The incorporation of PtW nanocrystals and MoS2 nanosheets in conjunction with each other to form hybrid nanocomposite improves the selective interaction of H2O2 with sensing material surface, and further increases the sensitivity and selectivity of sensor.

Keywords: H(2)O(2); Hybrid nanocomposite; Living cell; MoS(2); PtW.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Biosensing Techniques*
Cell Line, Tumor
Humans
Hydrogen Peroxide / isolation & purification*
Limit of Detection
Metal Nanoparticles / chemistry*
Molybdenum / chemistry
Nanocomposites / chemistry*
Oxidation-Reduction
Platinum / chemistry

Substances

Platinum
Molybdenum
Hydrogen Peroxide