Pancreas Transplantation in the Modern Era

Robert R Redfield; Michael R Rickels; Ali Naji; Jon S Odorico

doi:10.1016/j.gtc.2015.10.008

Pancreas Transplantation in the Modern Era

Gastroenterol Clin North Am. 2016 Mar;45(1):145-66. doi: 10.1016/j.gtc.2015.10.008. Epub 2016 Jan 13.

Authors

Robert R Redfield¹, Michael R Rickels², Ali Naji³, Jon S Odorico⁴

Affiliations

¹ Division of Transplantation, Department of Surgery, University of Wisconsin School of Medicine and Public Health, 600 Highland Avenue, Clinical Science Cntr-H4/772, Madison, WI 53792, USA. Electronic address: rrredfield@wisc.edu.
² Division of Endocrinology, Diabetes & Metabolism, Department of Medicine, University of Pennsylvania Perelman School of Medicine, 2-134 Smilow Center for Translational Research, 3400 Civic Center Boulevard, Philadelphia, PA 19104, USA.
³ Division of Transplantation, Department of Surgery, University of Pennsylvania Perelman School of Medicine, 3400 Spruce Street, Philadelphia, PA 19104-4283, USA.
⁴ Division of Transplantation, Department of Surgery, University of Wisconsin School of Medicine and Public Health, 600 Highland Avenue, Clinical Science Cntr-H4/772, Madison, WI 53792, USA.

PMID: 26895686
DOI: 10.1016/j.gtc.2015.10.008

Abstract

The field of pancreas transplantation has evolved from an experimental procedure in the 1980s to become a routine transplant in the modern era. With short- and long-term outcomes continuing to improve and the significant mortality, quality-of-life, and end-organ disease benefits, pancreas transplantation should be offered to more patients. In this article, we review current indications, patient selection, surgical considerations, complications, and outcomes in the modern era of pancreas transplantation.

Keywords: Diabetes; Islet transplantation; Outcomes; Pancreas diseases; Pancreas transplantation.

Publication types

Review

MeSH terms

Diabetes Complications
Diabetes Mellitus, Type 1 / complications
Diabetes Mellitus, Type 1 / surgery*
Diabetes Mellitus, Type 2 / complications
Diabetes Mellitus, Type 2 / surgery
Diabetic Nephropathies / etiology
Diabetic Nephropathies / surgery
Donor Selection
Graft Rejection / prevention & control*
Humans
Immunosuppressive Agents / therapeutic use*
Islets of Langerhans Transplantation / methods*
Kidney Failure, Chronic / etiology
Kidney Failure, Chronic / surgery
Kidney Transplantation
Pancreas / injuries
Pancreas Transplantation / methods*
Pancreatitis, Chronic / surgery
Patient Selection*
Postoperative Complications
Treatment Outcome

Substances

Immunosuppressive Agents