Large moderately-differentiated ovarian Sertoli-Leydig cell tumor in a 13-year-old female: A case report

Oncol Lett. 2016 Feb;11(2):1110-1112. doi: 10.3892/ol.2015.3979. Epub 2015 Nov 30.

Abstract

Sertoli-Leydig cell tumor of the ovary, also known as androblastoma, is a rare neoplasm from the group of sex cord-stromal tumors of the ovary. The tumor accounts for <0.5% of all primary ovarian neoplasms. The clinical signs and symptoms of Sertoli-Leydig cell tumors can be associated with either hormonal production or the presence of a mass-occupying lesion. In the current study, a 13-year-old female was diagnosed with a stage Ic ovarian Sertoli-Leydig cell tumor following abdominal pain and distension. One month after a right oophorectomy, the follow-up magnetic resonance imaging scan was negative for residual or recurrent tumor. The overall 5-year survival rate for moderately-differentiated (grade 2) and poorly-differentiated (grade 3) Sertoli-Leydig cell tumors is 80%, and long-term follow-up is therefore highly advised in this patient.

Keywords: Sertoli-Leydig cell tumor; hyperthyroidism; masculinization; ovary.