Loss of Merlin/NF2 protects pancreatic β-cells from apoptosis by inhibiting LATS2

Cell Death Dis. 2016 Feb 18;7(2):e2107. doi: 10.1038/cddis.2016.21.

Authors

T Yuan¹, K D D Gorrepati¹, K Maedler^{1

2}, A Ardestani¹

Affiliations

¹ Islet Biology Laboratory, Centre for Biomolecular Interactions Bremen, University of Bremen, Bremen, Germany.
² German Center for Diabetes Research (DZD) project partner, University of Bremen, Bremen, Germany.

No abstract available

Publication types

Letter
Research Support, Non-U.S. Gov't

MeSH terms

Apoptosis*
Caspase 3 / metabolism
Humans
Insulin-Secreting Cells / cytology
Insulin-Secreting Cells / metabolism
Mechanistic Target of Rapamycin Complex 1
Multiprotein Complexes / metabolism
Neurofibromin 2 / antagonists & inhibitors
Neurofibromin 2 / genetics
Neurofibromin 2 / metabolism*
Poly(ADP-ribose) Polymerases / metabolism
Protein Serine-Threonine Kinases / antagonists & inhibitors
Protein Serine-Threonine Kinases / metabolism*
RNA Interference
RNA, Small Interfering / metabolism
Signal Transduction
TOR Serine-Threonine Kinases / metabolism
Tumor Suppressor Proteins / antagonists & inhibitors
Tumor Suppressor Proteins / metabolism*

Substances

Multiprotein Complexes
Neurofibromin 2
RNA, Small Interfering
Tumor Suppressor Proteins
Poly(ADP-ribose) Polymerases
LATS2 protein, human
Mechanistic Target of Rapamycin Complex 1
Protein Serine-Threonine Kinases
TOR Serine-Threonine Kinases
Caspase 3