We report a case of transapical mitral valve-in-valve implantation for a deteriorated bioprosthesis using the SAPIEN 3. Our patient, a 79-year-old man, with a history of mitral valve replacement 10 years before, presented with acute dyspnea due to mitral valve dysfunction. He was successfully treated with transapical implantation and had an uneventful recovery. Our case demonstrates the feasibility of using SAPIEN 3 in treating degenerated bioprosthetic mitral valves.