The harmful effect of indoxyl sulfate on neovascularization in chronic kidney disease

Laetitia Dou; Stéphane Burtey

doi:10.1016/j.kint.2015.12.030

The harmful effect of indoxyl sulfate on neovascularization in chronic kidney disease

Kidney Int. 2016 Mar;89(3):532-4. doi: 10.1016/j.kint.2015.12.030.

Authors

Laetitia Dou¹, Stéphane Burtey²

Affiliations

¹ Aix Marseille Université, Inserm, Vascular Research Center of Marseille UMR_S 1076, Marseille, France. Electronic address: laetitia.dou@univ-amu.fr.
² Aix Marseille Université, Inserm, Vascular Research Center of Marseille UMR_S 1076, Marseille, France; Assistance Publique-Hôpitaux de Marseille, CHU Conception, Centre de Néphrologie Dialyse Transplantation Rénale, Marseille, France.

PMID: 26880447
DOI: 10.1016/j.kint.2015.12.030

Abstract

Patients with chronic kidney disease display an impairment of neovascularization in ischemic tissues. Studies have suggested the involvement of the uremic toxin indoxyl sulfate by demonstrating that indoxyl sulfate affects endothelial progenitor cells. However, few data are available on the effects of indoxyl sulfate on neovascularization and on the mechanisms involved. The article by Hung et al. shows that indoxyl sulfate suppresses neovascularization in uremic mice by impairing endothelial progenitor cell function via the inhibition of hypoxia-induced hypoxia-inducible factor/interleukin-10/vascular endothelial growth factor signaling.

Publication types

Comment

MeSH terms

Animals
Humans
Indican / metabolism*
Interleukin-10
Renal Insufficiency, Chronic
Signal Transduction / drug effects
Vascular Endothelial Growth Factor A*

Substances

Vascular Endothelial Growth Factor A
Interleukin-10
Indican