Rhodium-Catalyzed/Copper-Mediated Tandem C(sp(2))-H Alkynylation and Annulation: Synthesis of 11-Acylated Imidazo[1,2-a:3,4-a']dipyridin-5-ium-4-olates from 2H-[1,2'-Bipyridin]-2-ones and Propargyl Alcohols

Ting Li; Zhiqiang Wang; Kun Xu; Wenmin Liu; Xu Zhang; Wutao Mao; Yongming Guo; Xiaolin Ge; Fei Pan

doi:10.1021/acs.orglett.6b00177

Rhodium-Catalyzed/Copper-Mediated Tandem C(sp(2))-H Alkynylation and Annulation: Synthesis of 11-Acylated Imidazo[1,2-a:3,4-a']dipyridin-5-ium-4-olates from 2H-[1,2'-Bipyridin]-2-ones and Propargyl Alcohols

Org Lett. 2016 Mar 4;18(5):1064-7. doi: 10.1021/acs.orglett.6b00177. Epub 2016 Feb 16.

Authors

Ting Li^{1

2}, Zhiqiang Wang¹, Kun Xu¹, Wenmin Liu¹, Xu Zhang¹, Wutao Mao¹, Yongming Guo¹, Xiaolin Ge¹, Fei Pan²

Affiliations

¹ College of Chemistry and Pharmaceutical Engineering, Nanyang Normal University , Nanyang, Henan 473061, China.
² Department of Chemistry, College of Chemistry and Chemical Engineering, Xiamen University , Xiamen 361005, China.

PMID: 26878938
DOI: 10.1021/acs.orglett.6b00177

Abstract

A rhodium-catalyzed/copper-mediated tandem C(sp(2))-H alkynylation and intramolecular annulation of 2H-[1,2'-bipyridin]-2-ones with propargyl alcohols for the synthesis of 11-acylated imidazo[1,2-a:3,4-a']dipyridin-5-ium-4-olates is described.

Publication types

Research Support, Non-U.S. Gov't